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MDA - a measure of free radical activity


MDA (Malondialdehyde) is a highly reactive three carbon dialdehyde produced as a byproduct of polyunsaturated fatty acid peroxidation and arachidonic acid metabolism. MDA readily combines with several functional groups on molecules including proteins, lipoproteins, and DNA. MDA-modified proteins may show altered physico-chemical behavior and antigenicity. Antibodies to MDA will help to visualize the MDA-adducts.

Lipid peroxidation is a well-established mechanism of cellular injury in both plants and animals, and is used as an indicator of oxidative stress in cells and tissues. Lipid peroxides, derived from polyunsaturated fatty acids, are unstable and decompose to form a complex series of compounds. These include reactive carbonyl compounds, which is the most abundant malondialdehyde (MDA). Therefore, measurement of malondialdehyde is widely used as an indicator of lipid peroxidation.

Increased levels of lipid peroxidation products have been associated with a variety of chronic diseases in both humans and model systems. MDA reacts readily with amino groups on proteins and other biomolecules to form a variety of adducts, including cross-linked products. MDA also forms adducts with DNA bases that are mutagenic and possibly carcinogenic. DNA-protein cross-links are another result of the reaction between DNA and MDA.


Looking for an effective antioxidant to control excessive free radicals?
Consider Osumex Flax Hulls which has a high ORAC** value of 19,600 and a powerful antioxidant. It is also a most nutritious fibre!


**ORAC (Oxygen Radical Absorbance Capacity) is a method of measuring antioxidant capacities of different foods


Osumex Free Radical Test kit - see sample kit below



Malondialdehyde (MDA) is a by-product of free radical activity and this is what the test kit measures.

It is recommended that you test at least once a week, if excessive free radical activity is found, until it is brought under control, or once a month or at least once every few months to make sure free radicals in the body are not running rampant!





The above information is provided for general educational purposes only. It is not intended to replace competent health care advice received from a knowledgeable healthcare professional. You are urged to seek healthcare advice for the treatment of any illness or disease.
Health Canada and the FDA (USA) have not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease.

 


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